DESIGN AND DEVELOPMENT OF A NOVEL DRUG DELIVERY SYSTEM FOR ENHANCED THERAPEUTIC EFFICACY

Authors

  • Tummala. Akshaya Priyadarshini Institute of Pharmaceutical Education and Research, 5TH Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Keywords:

Liposomes, Noisome, Transferosome, Nanoparticles, Ectosomes

Abstract

 The emergence of innovative drug delivery systems has transformed pharmacology, facilitating the precise and efficient administration of therapeutics to designated locations within the body. This extensive review offers a thorough analysis of the latest developments in drug delivery technologies, with a particular emphasis on nanoparticle systems, liposomes, hydrogels, and materials responsive to stimuli. Traditional drug delivery techniques frequently encounter challenges such as limited bioavailability, systemic toxicity, and insufficient targeting capabilities. Advanced methods of drug delivery that focus on understanding the pharmacokinetic and pharmacodynamic properties of pharmaceuticals are known as novel drug delivery systems or NDDS. The goals of these systems are to enhance drug bioavailability, reduce drug loss, and avoid negative effects. The term "novel drug delivery system" (NDDS) describes methods, compositions, apparatus, and systems for delivering a medicinal substance throughout the body as required to safely provide the intended therapeutic effects. The Advanced Novel Drug Delivery System (NDDS) represents a significant evolution in pharmaceutical sciences, focusing on enhancing drug efficacy, safety, and patient compliance. Current developments in our knowledge of the pharmacokinetic and pharmacodynamics behaviour of drugs provide a more logical framework for designing the best possible drug delivery system. It is understandable that multidisciplinary efforts will play a major role in the success of drug delivery research in the future.

Downloads

Download data is not yet available.

References

1. Kiranmai R, Renuka B, Chandu BR. Vitamin D as a promising anticancer agent. Int J Res Pharm Chem. 2012;2(2):636-649.

2. Reddy PD, Swarnalatha D. Recent advances in novel drug delivery systems. Int J Pharm Tech Res. 2010;2(3):2025-2027.

3. Santini JT Jr, Richards AC, Scheidt R, Cima MJ, Langer R. Microchips as controlled drug delivery devices. Angew Chem Int Ed. 2000;39(14):2396-2407.

4. Purasana RK, Sarkar S, Rawat N, Prakash A. A review on novel drug delivery system. 2021.

5. Nikalje AP. Nanotechnology and its applications in medicine. Med Chem. 2015;5(2):81-89.

6. Ziaie B, Baldi A, Lei M, Gu Y, Siegel RA. Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery. Adv Drug Deliv Rev. 2004;56(2):145-172.

7. Prasanthi G, Chandu BR, Pradeep Kumar Y, Swarnalatha D, Gopinath. Chemical pharmacology of khat leaves. J Glob Trends Pharm Sci. 2014;5(4):2024-2029.

8. Ting WW, Vest CD, Sontheimer RD. A review of conventional and new approaches to enhance local therapeutic permeability across the stratum corneum. Int J Dermatol. 2004;43(7):538-547.

9. Schafer-Korting M, Korting HC, Ponce-Pöschl E. Liposomal tretinoin for treating uncomplicated acne vulgaris. Clin Investig. 1994;72(12):1086-1091.

10. Vijayalakshmi P, Girish C, Mendham R, Rao CB, Nama S. A review on Alzheimer's disease. Int J Pharma Biosci. 2014;4(2):19-27.

11. Müller RH. Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. J Pharm Pharmacol. 2004;56(2):343-356.

12. Kaur D, Kumar S. Niosome: current status and future prospects. J Drug Deliv Ther. 2018;8(5):35-41.

13. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in bulk and pharmaceutical dosage forms. Trop J Pharm Res. 2011;10(4):489-495.

14. Vikas K, et al. Recent advances in NDDS (novel drug delivery systems) for delivery of antihypertensive drugs. Int J Drug Dev Res. 2011;3(1):252-259.

15. Awen BZ, Chandu BR, Ramalingam P, Nama S. Improvement of dissolution rate and bioavailability of piroxicam with Sapindus mukorossi. IJPIs J Pharmacol Toxicol. 2011.

16. Banker GS, Rhodes CT. Modern pharmaceutics. 2nd ed. New York: Marcel Dekker; 1979.

17. Lee VHL, Robinson JR. Ocular drug delivery. J Pharm Sci. 1979;68:673-684.

18. Zhao CX. Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery. Adv Drug Deliv Rev. 2013;65:1420-1446.

19. Bergeson SM. Active drug delivery systems. Philadelphia (PA): Lippincott Williams & Wilkins; 2012.

20. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in solid dosage forms. Trop J Pharm Res. 2011;10(4):489-495.

21. Rani CU, Sumalatha G, Rao CB, Varalakshmi TN. Alzheimer’s disease-pharmacotherapeutic interventions. Int J Pharm Chem Sci. 2013;2(2).

Downloads

Published

2026-06-20

How to Cite

[1]
Tummala, A. 2026. DESIGN AND DEVELOPMENT OF A NOVEL DRUG DELIVERY SYSTEM FOR ENHANCED THERAPEUTIC EFFICACY. Journal of Drug Reactions. 2, 2 (Jun. 2026), 6–9.

Issue

Section

Articles