Transethosomes as Drug Carrier and Its Efficiency

Abstract

The development of efficient drug delivery systems remains a major focus of modern pharmaceutical research to overcome the limitations associated with conventional dosage forms, such as poor bioavailability, inadequate skin permeation, frequent dosing, and systemic adverse effects. Among the various nanocarrier-based approaches, transethosomes have emerged as an advanced generation of ultra-deformable lipid vesicles with significant potential for topical and transdermal drug delivery. Transethosomes are composed of phospholipids, ethanol, edge activators (surfactants), and water, integrating the advantages of both ethosomes and transferosomes. The synergistic interaction of ethanol and edge activators enhances vesicular flexibility, allowing these carriers to efficiently penetrate the highly resistant stratum corneum and deliver drugs into deeper layers of the skin or systemic circulation.Transethosomes exhibit excellent encapsulation efficiency for hydrophilic, lipophilic, and amphiphilic drugs, providing improved physicochemical stability, controlled and sustained drug release, enhanced skin retention, targeted drug delivery, and increased bioavailability. Their unique structural characteristics minimize drug degradation and reduce systemic toxicity while improving therapeutic efficacy and patient compliance.